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KMID : 0365819640040010019
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Journal of Pusan Medical College
1964 Volume.4 No. 1 p.19 ~ p.41
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Experimental Study of Procaine Therapy
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Abstract
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Procaine hydrochloride is effective in the treatment of experimental allergie cholecystitis in rabbits, as it was found and discussed in Part I. The author undertook another experiment on rabbits to clarify the effect of procanine on the bacteriological suppurative inflammation.
For this experiment, the skin of the abdomen of rabbits was prepared, since this region was easily observed and handled. A suspension of Staphylococcus aureus obtained and prepared from a subcutaneous abscess,and Streptococcus viridans from a mastoid abscess of human patients was injected intracutaneously into the abdomens of rabbits to cause suppurative inflammation. Then the animals were divided into 4 groups as below, to observe the effectiveness of procaine therapy.
Group A: A suspension of cocci was injected, only.
Group B: A suspension of cocci was injected and Ringer s solution was infiltrated on
and around the inflammation area, for a control to procaine therapy.
Group C: A suspension of cocci was injected and immediately after the injection, procaine infiltration therapy was given.
Group D: 12 hours after the injection of a suspension of cocci, procaine therapy was begun.
With time interval of 6, 12, 24, 36, 48 and 72 hours, specimens were taken from the injected inflammatory sites from each group of animals for patho-histological study.
The results are summarized as follows:
1) The degree of inflammatory reaction in each animal is different in proportion to the amount of the suspension of staphylo or strepto-cocci injected.
2) The staphylococci tend to remain confined to the injected area, and produce a more severe degree of inflammatory reaction than the streptococci. O n the contrary, streptococci tend to spread to a distance before the inflammatory reaction manifests itself.
3) In case of the inflammation caused by injection of a relatively large amount of the cocci, procaine accelerates the inflammation and progresses into suppuration.
4) Procaine therapy caused the suppression and absorption of the inflammation of relatively minor degree which, in case of no procaine therapy, progressed into suppuration.
5) Procaine promoted the return of normal circulation in the peripheral dysfunctioning capillary units and subsequently inhibited the inflammatory process, and accelerated the absorption of the debris.
6) Procaine therapy had better result in streptococcal than in the staphylococcal inflammation.
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